Which gland is primarily responsible for responding to changes in temperature such as during a fever?

The eccrine gland is primarily responsible for regulating body temperature through sweating, which is particularly important during events such as a fever. When the body's temperature rises, the eccrine glands produce sweat that evaporates from the skin's surface, helping to cool the body down. This is part of the body's thermoregulatory mechanism, allowing it to respond effectively to changes in temperature.

In contrast, apocrine glands primarily produce sweat in response to emotional stress rather than temperature regulation. Sebaceous glands secrete oil (sebum) to lubricate the skin and hair but do not play a significant role in thermoregulation. The pituitary gland is involved in hormone regulation and can influence body temperature indirectly by controlling other glands, but it does not directly respond to temperature changes in the way eccrine glands do.